| Secretary of State | James A. Baker 3d, 1989 Lawrence S. Eagleburger, 1992 |
| Secretary of the Treasury | Nicholas F. Brady (Cont.) |
| Secretary of Defense | Richard Cheney, 1989 |
| Attorney General | Richard L. Thornburgh (Cont.) William P. Barr, 1992 |
| Secretary of the Interior | Manuel Lujan Jr., 1989 |
| Secretary of Agriculture | Clayton K. Yeutter, 1989 Edward Madigan, 1991 |
| Secretary of Commerce | Robert A. Mosbacher Sr., 1989 Barbara H. Franklin, 1992 |
| Secretary of Labor | Elizabeth H. Dole, 1989 Lynn Martin, 1991 |
| Secretary of Health and Human Services | Louis W. Sullivan, 1989 |
| Secretary of Housing and Urban Development | Jack F. Kemp, 1989 |
| Secretary of Transportation | Samuel K. Skinner, 1989 Andrew Card, 1992 |
| Secretary of Energy | James D. Watkins, 1989 |
| Secretary of Education | Lauro F. Cavazos (Cont.) Lamar Alexander, 1991 |
| Secretary of Veterans Affairs | Edward J. Derwinski, 1989 |